Khalid A. Fakhro PhD

Chief Research Officer
Director – Precision Medicine Program
Principal Investigator – Full Level Laboratory of Genomic Medicine

Email: kfakhro (@) sidra.org

SELECTED PUBLICATIONS (equal contribution, *corresponding):

  • Pasquier J, Spurgeon M, Bradic M, Thomas B, Robay A, Chidiac O, Dib MJ, Turjoman R, Liberska A, Staudt M, Fakhro KA, Menzies R, Jayyousi A, Zirie M, Suwaidi JA, Malik RA, Talal T, Rafii A, Mezey J, Rodriguez-Flores J, Crystal RG, Abi Khalil C. Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts. Epigenomics (2019) 11(3):281-296.
  • Da'as SI, Fakhro K, Thanassoulas A, Krishnamoorthy N, Saleh A, Calver BL, Safieh-Garabedian B, Toft E, Nounesis G, Lai FA, Nomikos M. Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction. Biochem J (2018) 475(24):3933-3948.
  • Fakhro KA, Elbardisi H, Arafa M, Robay A, Rodriguez-Flores JL, Al-Shakaki A, Syed N, Mezey JG, Abi Khalil C, Malek JA, Al-Ansari A, Al Said S, Crystal RG. Point-of-care whole-exome sequencing of idiopathic male infertility. Genet Med (2018) 20(11):1365-1373
  • Yousri NA*, Fakhro KA*, Robay A, Rodriguez-Flores JL, Mohney RP, Zeriri H, Odeh T, Kader SA, Aldous EK, Thareja G, Kumar M, Al-Shakaki A, Chidiac OM, Mohamoud YA, Mezey JG, Malek JA, Crystal RG, Suhre K. Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population. Nat Commun (2018) 9(1):333
  • Fadda A, Butt F, Tomei S, Deola S, Lo B, Robay A, Al-Shakaki A, Al-Hajri N, Crystal R, Kambouris M, Wang E, Marincola FM, Fakhro KA, Cugno C. Two hits in one: whole genome sequencing unveils LIG4 syndrome and urofacial syndrome in a case report of a child with complex phenotype. BMC Med Genet (2016) 17(1):84.
  • Fakhro KA, Staudt MR, Ramstetter MD, Robay A, Malek JA, Badii R, Al-Marri AA, Abi Khalil C, Al-Shakaki A, Chidiac O, Stadler D, Zirie M, Jayyousi A, Salit J, Mezey JG, Crystal RG, Rodriguez-Flores JL. The Qatar genome: a population-specific tool for precision medicine in the Middle East. Hum Genome Var (2016) 3:16016.
  • Rodriguez-Flores JL*, Fakhro KA*, Agosto-Perez F, Ramstetter MD, Arbiza L, Vincent TL, Robay A, Malek JA, Suhre K, Chouchane L, Badii R, Al-Nabet Al-Marri A, Abi Khalil C, Zirie M, Jayyousi A, Salit J, Keinan A, Clark AG, Crystal RG, Mezey JG. Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations. Genome Res (2011) 26(2):151-62.
  • Fakhro KA, Yousri NA, Rodriguez-Flores JL, Robay A, Staudt MR, Agosto-Perez F, Salit J, Malek JA, Suhre K, Jayyousi A, Zirie M, Stadler D, Mezey JG, Crystal RG. Copy number variations in the genome of the Qatari population. BMC Genomics (2015) 16:834.
  • Rodriguez-Flores JL*, Fakhro K*, Hackett NR, Salit J, Fuller J, Agosto-Perez F, Gharbiah M, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chouchane L, Stadler DJ, Mezey JG, Crystal RG. Exome sequencing identifies potential risk variants for Mendelian disorders at high prevalence in Qatar. Hum Mutat (2014)35(1):105-16.
  • Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M. Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A (2011)108(7):2915-20.